This series of activities is comprised of abbreviated slide sets along with edited commentary from clinical investigators summarizing the significance of results presented at the ASCO 2011 Annual Meeting. Solid tumors that are highlighted include melanoma, GIST and breast, lung, ovarian, colorectal and genitourinary cancers. Hematologic cancers and related disorders that are highlighted include acute and chronic lymphoid and myeloid leukemias, myelodysplastic syndromes, myelofibrosis, multiple myeloma and diffuse large B-cell lymphoma.