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Tx for 63 yo pt with WM requiring treatment, normal renal function, no PN?Tx for 63 yo pt with WM requiring treatment, normal renal function, no PN?A 63-year-old man with normal renal function and no peripheral neuropathy is diagnosed with Waldenström macroglobulinemia (WM) and requires treatment. What would be your most likely front-line treatment recommendation?
Buske C, Leblond V. How to manage Waldenstrom’s macroglobulinemia. Leukemia 2013;27(4):762-72. Abstract Buske C et al. Waldenstrom’s macroglobulinaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24(Suppl 6):155-9. Abstract Dimopoulos MA et al. Treatment recommendations for patients with Waldenström macroglobulinemia (WM) and related disorders: IWWM-7 consensus. Blood 2014;124(9):1404-11. Abstract Dimopoulos MA et al. Primary therapy of Waldenstrom macroglobulinemia (WM) with weekly bortezomib, low-dose dexamethasone, and rituximab (BDR): Long-term results of a phase 2 study of the European Myeloma Network (EMN). Blood 2013;122(19):3276-82. Abstract Owen RG et al. Guidelines on the diagnosis and management of Waldenström macroglobulinaemia. Br J Haematol 2014;165(3):316-33. Abstract Vos JM et al. HOVON Multiple Myeloma Working Party; HOVON Lymphoma Working Party. Guideline for diagnosis and treatment of Waldenström’s macroglobulinaemia. Neth J Med 2013;71(2):54-62. Abstract |