Join us on Wednesday, January 27^th for this CME-accredited webinar
5:00 PM – 6:30 PM ET

This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group, and Merck.

Not an official event of the 2021 Gastrointestinal Cancers Symposium. Not sponsored, endorsed, or accredited by any of the cosponsoring organizations of the 2021 Gastrointestinal Cancers Symposium.

Wednesday, January 27, 2021
5:00 PM – 6:30 PM Eastern Time
Live CME-accredited webinar

Topics to Be Discussed

• Front-Line Management Options for Advanced Hepatocellular Carcinoma (HCC)
• Selection and Sequencing of Treatment for Patients with Relapsed HCC
• Considerations for the Treatment of HCC in Special Patient Populations
• New Directions in the Management of HCC

A detailed agenda will be provided in the coming weeks.

Target Audience
This activity is intended for medical oncologists, hematology-oncology fellows, surgeons and other healthcare professionals involved in the treatment of gastrointestinal cancer.

Learning Objectives
Upon completion of this activity, participants should be able to

• Consider age, performance status, degree of liver function and other clinical factors in the selection of up-front and later-line therapy for patients with unresectable or metastatic hepatocellular carcinoma (HCC).
• Acknowledge available Phase III data with and the FDA approval of lenvatinib as first-line treatment for unresectable HCC, and discern how this agent can be optimally integrated into the clinical care of patients.
• Evaluate Phase III data leading to the recent FDA approval of atezolizumab in combination with bevacizumab as first-line therapy for patients with newly diagnosed unresectable or metastatic HCC, and incorporate this novel regimen into clinical management algorithms.
• Develop personalized treatment plans for patients with HCC and compromised liver function that take into account the unique therapeutic needs and toxicity considerations of these individuals.
• Establish an evidence-based approach to the selection and sequencing of available therapeutic options for patients with progressive HCC.
• Maintain an understanding of the side effects and toxicities associated with targeted agents and immunotherapeutic approaches used in the management of advanced HCC, and intervene with early and effective responses to various adverse events.
• Recall available and emerging data with investigational agents and strategies currently in clinical testing for HCC, and where applicable, refer eligible patients for trial participation.

CME Credit Form
A CME credit form will be emailed to participants within 3 business days of the activity.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — Dr Greten has no relevant conflicts of interest to disclose. The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

Dr Finn — Consulting Agreements: Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, CStone Pharmaceuticals, Genentech, a member of the Roche Group, Lilly, Merck, Pfizer Inc; Contracted Research: Bristol-Myers Squibb Company, Eisai Inc, Genentech, a member of the Roche Group, Lilly, Merck, Pfizer Inc; Data and Safety Monitoring Board/Committee: AstraZeneca Pharmaceuticals LP. Dr Harding — Consulting Agreements: Bristol-Myers Squibb Company, CytomX Therapeutics, Eisai Inc, Exelixis Inc, Imvax, Lilly, Merck; Contracted Research: Bristol-Myers Squibb Company; Data and Safety Monitoring Board/Committee: Merck. Dr Kaseb — Advisory Committee and Consulting Agreements: Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group; Contracted Research: Adaptimmune, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group, Hengrui Therapeutics Inc.

MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies Corporation, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, EMD Serono Inc, Epizyme Inc, Exact Sciences Inc, Exelixis Inc, Foundation Medicine, Genentech, a member of the Roche Group, Genmab, Gilead Sciences Inc, GlaxoSmithKline, Grail Inc, Guardant Health, Halozyme Inc, Helsinn Healthcare SA, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Novocure Inc, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seagen Inc, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Sumitomo Dainippon Pharma Oncology Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, A GSK Company, Teva Oncology, Tokai Pharmaceuticals Inc and Verastem Inc.

Research To Practice CME Planning Committee Members, Staff and Reviewers — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

Supporters
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group, and Merck.