Virtual Meetings 2023

Meet The Professor: Optimizing the Management of ER-Positive and Triple-Negative Breast Cancer

For an up-to-date schedule of upcoming sessions in this series, please click here.

PARTICIPATING FACULTY

Sara A Hurvitz, MD
Professor of Medicine
Director, Breast Cancer Clinical Trials Program, Division of Hematology-Oncology
David Geffen School of Medicine at UCLA
Los Angeles, California

Komal Jhaveri, MD
Associate Attending Physician
Breast Medicine Service and Early Drug Development Service
Section Head, Endocrine Therapy Research Program
Clinical Director, Early Drug Development Service
Department of Medicine
Memorial Sloan Kettering Cancer Center
Assistant Professor of Medicine
Weill Cornell College of Medicine
New York, New York



Sara M Tolaney, MD, MPH
Chief, Division of Breast Oncology
Associate Director, Susan F Smith Center
for Women's Cancers
Senior Physician
Dana-Farber Cancer Institute
Associate Professor of Medicine
Harvard Medical School
Boston, Massachusetts

SERIES MODERATOR
Neil Love, MD
Research To Practice
 

These activities are supported by educational grants from AstraZeneca Pharmaceuticals LP, Exact Sciences Corporation, Sanofi, and TerSera Therapeutics LLC.

Agenda

Each 1-hour session will be divided into topic modules focused on current management, emerging research and novel agents and strategies under active investigation for breast cancer. Each event will employ an identical format that will include the following elements:

  • Moderator Dr Neil Love and a featured participating clinical investigator
  • Discussion of participating faculty treatment recommendations
  • Review of available clinical research findings
  • Community oncologist video case presentations
  • Interactive audience polling and extensive Q&A

    MODULE 1: Current Approaches to Treatment Decision-Making for Patients with ER-Positive Localized Breast Cancer

    MODULE 2: Integration of Novel Therapies into the Care of Patients with Localized Triple-Negative Breast Cancer (TNBC)

    MODULE 3: Current and Future Treatment Considerations for ER-Positive Metastatic Breast Cancer

    MODULE 4: Selection and Sequencing of Therapy for Metastatic TNBC

Target Audience
This program is intended for medical oncologists, hematologists, hematology-oncology fellows, breast surgeons, radiation oncologists, oncology nurses and other allied healthcare professionals involved in the treatment of breast cancer.

Learning Objectives

  • Evaluate the results of genomic assays and other patient- and treatment-related factors to personalize the use of adjuvant systemic therapy for patients with newly diagnosed ER-positive, HER2-negative breast cancer.
  • Review available research with the use of commercially available CDK4/6 inhibitors for the treatment of ER-positive localized and metastatic breast cancer, and optimally incorporate these agents into patient care.
  • Interrogate published research findings documenting the efficacy of various novel agents (eg, selective estrogen receptor degraders, AKT inhibitors) for patients with progressive ER-positive metastatic breast cancer (mBC) to determine the potential clinical applicability of these approaches.
  • Evaluate published research findings guiding the selection of available therapeutic agents for patients with localized and metastatic triple-negative breast cancer.
  • Appraise published efficacy and safety data with PARP inhibitors for patients with localized and metastatic breast cancer harboring BRCA1/2 mutations, and consider the diagnostic and therapeutic implications for nonresearch care.
  • Appreciate the clinical relevance of HER2-low mBC, and understand available and emerging management approaches for this disease subset.
  • Assess early data with and ongoing clinical trials evaluating novel agents and treatment strategies under development for ER-positive and triple-negative breast cancer.

CE Credit
CME and ABIM MOC credit form links will be emailed to each participant within 5 business days of the activity.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates each live activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine (ABIM) — Maintenance of Certification (MOC)
Successful completion of each CME activity, which includes participation in the evaluation component and a short post-test, enables the participant to earn up to 1 Medical Knowledge MOC point in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Please note, this program has been specifically designed for the following ABIM specialty: medical oncology.

Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information. For those clinicians wishing to receive ABIM MOC credit for attending, you will receive an email after the event with instructions.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest will have been mitigated prior to the commencement of each activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

Dr Hurvitz — Contracted Research: Ambrx, Amgen Inc, Arvinas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Celcuity, CytomX Therapeutics, Daiichi Sankyo Inc, Dantari, Dignitana AB, G1 Therapeutics Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Greenwich LifeSciences Inc, GSK, Lilly, MacroGenics Inc, Novartis, OBI Pharma Inc, Orinove Inc, Orum Therapeutics, Pfizer Inc, Phoenix Molecular Designs, Pieris Pharmaceuticals Inc, Puma Biotechnology Inc, Radius Health Inc, Samumed, Sanofi, Seagen Inc, Stemline Therapeutics Inc, Zymeworks Inc; Nonrelevant Financial Relationship: Ideal Implant (spouse). Dr Jhaveri — Consulting Agreements: AbbVie Inc, AstraZeneca Pharmaceuticals LP, Blueprint Medicines, Bristol-Myers Squibb Company, Daiichi Sankyo Inc, Eisai Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Jounce Therapeutics, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Menarini Group, Novartis, Olema Oncology, Pfizer Inc, Seagen Inc, Stemline Therapeutics Inc, Sun Pharma Advanced Research Company Ltd, Taiho Oncology Inc; Contracted Research: AstraZeneca Pharmaceuticals LP, Context Therapeutics, Debiopharm, Genentech, a member of the Roche Group, Gilead Sciences Inc, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Novartis, Pfizer Inc, Puma Biotechnology Inc, Zymeworks Inc. Dr Tolaney — Consulting Agreements: 4D Pharma PLC, Aadi Bioscience, ARC Therapeutics, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, BeyondSpring Pharmaceuticals Inc, Blueprint Medicines, Bristol-Myers Squibb Company, CytomX Therapeutics, Daiichi Sankyo Inc, Eisai Inc, Ellipses Pharma, Genentech, a member of the Roche Group, Gilead Sciences Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Lilly, Menarini Group, Merck, Myovant Sciences, Novartis, OncoSec Medical, OncXerna Therapeutics Inc, Pfizer Inc, Reveal Genomics, Sanofi, Seagen Inc, Stemline Therapeutics Inc, Umoja Biopharma, Zentalis Pharmaceuticals, Zetagen, Zymeworks Inc; Contracted Research: AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Cyclacel Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Lilly, Merck, NanoString Technologies, Nektar, Novartis, Pfizer Inc, Sanofi, Seagen Inc.

SURVEY PARTICIPANTS — Harold J Burstein, MD, PhD and Ann Partridge, MD, MPH — No relevant conflicts of interest to disclose. Kathy D Miller, MD — Contracted Research: Astex Pharmaceuticals, Pfizer Inc, Radiopharm Theranostics (not yet active); Data and Safety Monitoring Board/Committee: AstraZeneca Pharmaceuticals LP, Celcuity, Genentech, a member of the Roche Group, Merck. Laura Spring, MD — Advisory Committee: AstraZeneca Pharmaceuticals LP; Consulting Agreements: AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, G1 Therapeutics Inc, Novartis, Puma Biotechnology Inc; Contracted Research: Genentech, a member of the Roche Group, Gilead Sciences Inc, Lilly, Merck, Philips. Melinda Telli, MD — Advisory Committee: AstraZeneca Pharmaceuticals LP, Blueprint Medicines, Daiichi Sankyo Inc, G1 Therapeutics Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, GSK, Guardant Health, Immunomedics Inc, Lilly, Merck, Natera Inc, Novartis, Pfizer Inc, RefleXion, Replicate Bioscience, Sanofi; Contracted Research: AbbVie Inc, Bayer HealthCare Pharmaceuticals, Biothera Pharmaceuticals Inc, Calithera Biosciences, EMD Serono Inc, Genentech, a member of the Roche Group, GSK, Hummingbird Bioscience, Medivation Inc, a Pfizer Company, Novartis, OncoSec Medical, Pfizer Inc, PharmaMar, Tesaro, A GSK Company, Vertex Pharmaceuticals; Data and Safety Monitoring Board/Committee: G1 Therapeutics Inc, Gilead Sciences Inc.

SERIES MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: AbbVie Inc, Adaptive Biotechnologies Corporation, ADC Therapeutics, Agios Pharmaceuticals Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeiGene Ltd, BeyondSpring Pharmaceuticals Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Coherus BioSciences, CTI BioPharma Corp, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, EMD Serono Inc, Epizyme Inc, Exact Sciences Corporation, Exelixis Inc, Five Prime Therapeutics Inc, Foundation Medicine, G1 Therapeutics Inc, Genentech, a member of the Roche Group, Genmab US Inc, Gilead Sciences Inc, Grail Inc, GSK, Halozyme Inc, Helsinn Healthcare SA, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Kronos Bio Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, MEI Pharma Inc, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure Inc, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sanofi, Seagen Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Stemline Therapeutics Inc, Sumitomo Dainippon Pharma Oncology Inc, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, TerSera Therapeutics LLC, Tesaro, A GSK Company, TG Therapeutics Inc, Turning Point Therapeutics Inc, Verastem Inc, and Zymeworks Inc.

RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

Supporters
These activities are supported by educational grants from AstraZeneca Pharmaceuticals LP, Exact Sciences Corporation, Sanofi, and TerSera Therapeutics LLC.