Target Audience
This activity is intended for medical oncologists, hematologists, hematology-oncology fellows, radiation oncologists, surgeons and other allied healthcare professionals involved in the treatment of soft tissue sarcoma and related connective tissue disorders.

Learning Objectives
Upon completion of this activity, participants should be able to

• Recognize the histologic diversity of soft tissue sarcomas (STS), and appreciate the importance of appropriate assessment and accurate diagnosis to facilitate optimal treatment and long-term outcomes for patients.
• Consider the influence of patient age, histology, extent of disease and other clinical and biological factors on the selection and sequencing of therapy for STS.
• Explore the clinical trial database supporting the use of agents such as multitargeted tyrosine kinase inhibitors, TRK inhibitors, mTOR inhibitors and EZH2 inhibitors that have demonstrated activity in various subtypes of STS, and use this information to identify patients for whom treatment with these strategies may be appropriate.
• Understand the incidence, risk factors, etiology and clinical presentation of desmoid tumors in order to optimally diagnose patients with this disease.
• Evaluate the scientific rationale for targeting the gamma secretase complex and Notch pathway as a therapeutic approach for desmoid tumors, and review available research establishing the efficacy and clinical role of this novel strategy.
• Assess the biological rationale for the evaluation of colony-stimulating factor-1 receptor inhibitors in the treatment of tenosynovial giant cell tumors, and consider the current role of these agents in patient care.
• Recall new data with investigational agents and strategies demonstrating promising activity for STS and other connective tissue disorders, and appropriately refer eligible patients for trial participation.

CME Credit Form
A CME credit form link will be emailed to each participant within 5 business days of the activity.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

Dr Chugh — Advisory Committees: Deciphera Pharmaceuticals Inc, Inhibrx, Recordati Rare Diseases; Contracted Research: Adaptimmune, Astex Pharmaceuticals, Ayala Pharmaceuticals, Cogent Biosciences, Inhibrx, Kronos Bio, Pfizer Inc, PharmaMar, Polaris Pharmaceuticals. Dr Gounder — Advisory Committees: Aadi Bioscience, Boehringer Ingelheim Pharmaceuticals Inc, Epizyme Inc, Ikena Oncology, Rain Oncology, Regeneron Pharmaceuticals Inc; Consulting Agreements: Ayala Pharmaceuticals, Kura Oncology; Contracted Research: Aadi Bioscience, Athenex, Ayala Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals Inc, Erasca, Foghorn Therapeutics, GSK, Ikena Oncology, Kura Oncology, Rain Oncology, Regeneron Pharmaceuticals Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Tango Therapeutics.

MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: Aadi Bioscience, AbbVie Inc, ADC Therapeutics, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Arvinas, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeiGene Ltd, Black Diamond Therapeutics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, Clovis Oncology, Coherus BioSciences, CTI BioPharma, a Sobi Company, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, Exact Sciences Corporation, Exelixis Inc, Genentech, a member of the Roche Group, Genmab US Inc, Geron Corporation, Gilead Sciences Inc, GSK, Hologic Inc, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Kura Oncology, Legend Biotech, Lilly, MEI Pharma Inc, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Mural Oncology Inc, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure Inc, Nuvalent, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Rigel Pharmaceuticals Inc, R-Pharm US, Sanofi, Seagen Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Stemline Therapeutics Inc, Syndax Pharmaceuticals, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, TerSera Therapeutics LLC, and Tesaro, A GSK Company.

RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS
Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

Supporters
This activity is supported by educational grants from Aadi Bioscience and SpringWorks Therapeutics Inc.