Location
Walter E Washington Convention Center
801 Allen Y Lew Place NW
Washington, DC 20001
Phone: (202) 249-3000
Program Schedule — Eastern Time
5:00 PM – 5:30 PM — Registration and Dinner
5:30 PM – 7:30 PM — Educational Meeting
Meeting Room
Ballroom A, Third Level
No registration fee is charged for this event. For the in-person symposium in Washington, DC, preregistration is required to ensure seating.
Faculty Neeraj Agarwal, MD, FASCO
Professor of Medicine
Senior Director for Clinical Research
Huntsman Cancer Institute Presidential Endowed Chair of Cancer Research
Director, Center of Investigational Therapeutics
Huntsman Cancer Institute, University of Utah (NCI-CCC)
Salt Lake City, Utah
Daniel P Petrylak, MD
Professor of Medicine and Urology
Director, Genitourinary Oncology Research Program
Co-Director, Signal Transduction Program
Yale Comprehensive Cancer Center
Yale School of Medicine
New Haven, Connecticut
Fred Saad, CQ, MD
Professor and Chairman
Department of Surgery
University of Montreal Hospital Center (CHUM)
Montréal, Québec, Canada
Neal D Shore, MD
Director, START Carolinas/Carolina Urologic Research Center
Head of GU Oncology START Research
AUC Atlantic Urology Specialists
Myrtle Beach, South Carolina
Moderator Elisabeth I Heath, MD
Chair, Department of Oncology
Mayo Clinic
Rochester, Minnesota
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP and Merck.
Program Schedule — Eastern Time
5:00 PM – 5:30 PM — Registration and Dinner
5:30 PM – 7:30 PM — Educational Meeting
MODULE 1: Evolving Management of Nonmetastatic Hormone-Sensitive Prostate Cancer (nmHSPC)
Indications for and selection of androgen deprivation therapy (ADT) for prostate cancer; key efficacy and safety data with and optimal integration of the oral GnRH antagonist relugolix into current practice
Rationale for the evaluation of treatment intensification with androgen receptor (AR) pathway inhibitors for nmHSPC
Major efficacy and safety data, including overall survival outcomes, from the Phase III EMBARK trial evaluating enzalutamide with leuprolide versus enzalutamide or leuprolide alone for patients with nmHSPC and high-risk biochemical recurrence after definitive therapy
FDA approval of enzalutamide with and without ADT and optimal application in clinical practice
Published data with ADT intensification with apalutamide with or without abiraterone for patients with high-risk, biochemically recurrent nmHSPC
Other ongoing Phase III studies evaluating AR pathway inhibitors for patients with nmHSPC
MODULE 2: Current Hormonal Treatment for Metastatic HSPC (mHSPC)
Extended follow-up with abiraterone, enzalutamide and apalutamide in combination with ADT for patients with mHSPC
Published data from the Phase III ARANOTE study supporting the recent FDA approval of darolutamide/ADT for mHSPC
Clinical factors guiding the selection of a specific AR pathway inhibitor for patients with mHSPC; available datasets exploring the relative benefit of various approved agents
Published efficacy and safety data from the Phase III ARASENS trial evaluating darolutamide in combination with docetaxel and ADT for mHSPC
Selection of optimal candidates with mHSPC for triplet therapy with darolutamide/docetaxel/ADT
MODULE 3: Current and Future Role of PARP Inhibitors for Metastatic Prostate Cancer (mPC)
Incidence and clinical implications of BRCA1/2 and other homologous recombination repair (HRR) abnormalities in patients with mPC; recommended timing and optimal method for genetic testing
Long-term efficacy and safety findings with olaparib/abiraterone, niraparib/abiraterone and talazoparib/enzalutamide, respectively, in the first-line setting for metastatic castration-resistant prostate cancer (mCRPC)
FDA-approved indications for olaparib/abiraterone, niraparib/abiraterone and talazoparib/enzalutamide for mCRPC; appropriate selection of a PARP inhibitor/secondary hormonal therapy combination for individual patients
Published data from the Phase III AMPLITUDE trial evaluating the addition of niraparib to abiraterone/prednisone for patients with mHSPC harboring alterations in homologous recombination repair genes
Recent FDA approval of niraparib in combination with abiraterone/prednisone for patients with BRCA2-mutated mHSPC; optimal integration into current management algorithms
Mechanistic similarities and differences between saruparib and other PARP inhibitors; ongoing efforts evaluating saruparib and other PARP inhibitors for mHSPC and in earlier settings
MODULE 4: Emerging Role of AKT Inhibition for Patients with mHSPC
Biological justification for targeting the PI3K/AKT/mTOR pathway with capivasertib in prostate cancer; rationale for benefit in patients with PTEN-deficient disease
Frequency of PTEN deficiency in prostate cancer; indications for and optimal timing of and approach to PTEN assessment
Design, eligibility criteria and primary and secondary endpoints of the Phase III CAPItello-281 trial assessing capivasertib with abiraterone/ADT for patients with de novo mHSPC and PTEN deficiency
Recently presented positive results from CAPItello-281 with the addition of capivasertib to abiraterone/ADT for PTEN-deficient mHSPC
Spectrum of toxicities associated with capivasertib; recommended monitoring and management strategies
Potential integration of capivasertib/abiraterone/ADT into mHSPC treatment algorithms; optimal use compared to other currently available regimens
MODULE 5: Current and Future Use of Radiopharmaceuticals for mPC
Long-term data with and current role of radium-223 monotherapy in current mCRPC treatment algorithms
Key efficacy and safety findings from the Phase III PEACE-3 trial of radium-223 and enzalutamide versus enzalutamide alone as first-line therapy for mCRPC with bone metastases; implications for clinical management
Published Phase III datasets with lutetium Lu 177 vipivotide tetraxetan for patients with taxane-naïve and taxane-pretreated, PSMA-positive mCRPC; appropriate sequencing opposite other available therapies
Recently presented results from the Phase III PSMAddition study evaluating the addition of lutetium Lu 177 vipivotide tetraxetan to hormonal therapy for patients with PSMA-positive mHSPC; implications for clinical practice
Early findings with and ongoing evaluation of other novel radiopharmaceuticals for mPC
Target Audience
This activity has been designed to meet the educational needs of urologists, medical and radiation oncologists and other allied healthcare professionals involved in the treatment of prostate cancer.
Learning Objectives
Upon completion of this activity, participants should be able to
Infer how various clinical and biological factors affect the risk of prostate cancer recurrence after local therapy, and design appropriate treatment plans for individual patients considering the potential benefits and risks of new and established forms of hormonal therapy.
Appraise published research findings on optimal management approaches for biochemical recurrence after local treatment for prostate cancer, and counsel appropriate patients regarding the potential benefits of FDA-approved systemic treatment options.
Evaluate the published research database supporting the FDA approvals of secondary hormonal agents for the management of nonmetastatic prostate cancer, and apply this information in the discussion of nonresearch treatment options.
Explore available data with treatment intensification with cytotoxic therapy, secondary hormonal therapy or combinations of these approaches for metastatic hormone-sensitive prostate cancer (mHSPC), and effectively integrate these strategies into current clinical management algorithms.
Assess the available research database supporting the use of PARP inhibitors in combination with androgen receptor pathway inhibitors for patients with metastatic prostate cancer harboring a homologous recombination repair gene alteration, and discern how to optimally incorporate these agents into current clinical management algorithms.
Appreciate the biological rationale for targeting the PI3K/AKT/mTOR pathway for prostate cancer, and evaluate available data with novel AKT inhibitors in combination with hormonal therapy for patients with mHSPC and PTEN deficiency.
Review available Phase III data documenting the efficacy of various forms of radioligand therapy for metastatic prostate cancer, and consider the current and future clinical role of these strategies.
Recall the design of ongoing clinical trials evaluating other novel agents and strategies for prostate cancer, and counsel appropriate patients about availability and participation.
CME Credit Form
A CME credit link will be given to each participant as part of the meeting course materials.
Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation Statement
Research To Practice designates this live activity for a maximum of 2 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.
Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.
Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations. Financial disclosures will be provided.
FACULTY — Dr Agarwal and Dr Petrylak have no relevant financial relationships to disclose. The following faculty reported relevant financial relationships with ineligible entities:
EDITOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: Aadi Bioscience, AbbVie Inc, ADC Therapeutics, Agendia Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Arvinas, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeOne, Biotheranostics Inc, A Hologic Company, Black Diamond Therapeutics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, Celcuity, Clovis Oncology, Coherus BioSciences, Corcept Therapeutics Inc, CTI BioPharma, a Sobi Company, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, Exact Sciences Corporation, Exelixis Inc, Genentech, a member of the Roche Group, Genmab US Inc, Geron Corporation, Gilead Sciences Inc, GSK, Helsinn Therapeutics (US) Inc, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Jazz Pharmaceuticals Inc, Johnson & Johnson, Karyopharm Therapeutics, Kite, A Gilead Company, Kura Oncology, Legend Biotech, Lilly, MEI Pharma Inc, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Mural Oncology Inc, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure Inc, Nuvalent, Nuvation Bio Inc, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Revolution Medicines Inc, Rigel Pharmaceuticals Inc, R-Pharm US, Sanofi, Seagen Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Stemline Therapeutics Inc, Sumitomo Pharma America, Summit Therapeutics, Syndax Pharmaceuticals, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, TerSera Therapeutics LLC, and Tesaro, A GSK Company.
RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.
Supporters
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP and Merck.
Walter E Washington Convention Center
801 Allen Y Lew Place NW
Washington, DC 20001
Phone: (202) 249-3000
Meeting Room
Ballroom A, Third Level
Directions
The Walter E Washington Convention Center is the main venue for the 2026 AUA Annual Meeting.
This activity has been designed to meet the educational needs of urologists, medical and radiation oncologists and other allied healthcare professionals involved in the treatment of prostate cacner.
No registration fee is charged for this event. For the in-person symposium in Washington, DC, preregistration is required to ensure seating.
NOTICE: Registration for this event is independent of registration for the 2026 AUA Annual Meeting.
IN-PERSON Registration for clinicians in practice/healthcare professionals
I am a practicing physician, fellow, nurse or other healthcare provider involved in the treatment of cancer.
If you are registering a group (more than 1 person) for this event, please contact us at Meetings@ResearchToPractice.com or (800) 233-6153.
To ensure seating and meal service, please check in at our onsite registration desk before the start of the meeting. We cannot guarantee seating after the start of the program.
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Research To Practice fully complies with the legal requirements of the ADA. If you require any physical, dietary or other accommodations, please call us at (800) 233-6153 before the event.
