Sequencing of enzalutamide and abiraterone for chemo-naïve mCRPC?


Sequencing of enzalutamide and abiraterone for chemo-naïve mCRPC?

Regulatory and reimbursement issues aside, how would you generally sequence enzalutamide and abiraterone for patients with chemotherapy-naïve mCRPC?

 

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Fizazi K et al. Novel and bone-targeted agents for CRPC. Ann Oncol 2012;23(Suppl 10):x264-7. Abstract

Gomella LG et al. Current management of advanced and castration resistant prostate cancer. Can J Urol 2014;21(2 Suppl 1):1-6. Abstract

Hoskin P et al. Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: A prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial. Lancet Oncol 2014;15(12):1397-406. Abstract

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Scher HI et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 2012;367(13):1187-97. Abstract