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Switch Tx if pt only in PR prior to transplant?Switch Tx if pt only in PR prior to transplant?Are there situations in which a patient has only achieved a PR after planned induction prior to transplant and you would switch therapies in an attempt to achieve a deeper response?
Ahn Y et al. Early response-based intensification of primary therapy in newly diagnosed multiple myeloma patients who are eligible for autologous stem cell transplantation: Phase II study. Ann Hematol 2014;93(9):1571-7. Abstract Gertz MA et al. Stem cell transplantation in multiple myeloma: Impact of response failure with thalidomide or lenalidomide induction. Blood 2010;115(12):2348-53. Abstract Kim JS et al. Complete remission status before autologous stem cell transplantation is an important prognostic factor in patients with multiple myeloma undergoing upfront single autologous transplantation. Biol Blood Marrow Transplant 2009;15(4):463-70. Abstract Lee SF et al. Impact of failed response to novel agent induction in autologous stem cell transplantation for multiple myeloma. Ann Hematol 2014;93(4):627-34. Abstract |