Meet The Professors: Pancreatic Cancer Edition, 2016 - Video 16Rationale for the use of fixed dose-rate gemcitabine
0:45 minutes.
TRANSCRIPTION:
DR GLYNN: Just a quick question. So the gemcitabine, is that a prodrug? The FDR gemcitabine, is that a prodrug issue, or is that a cell penetration issue of getting higher concentration in the cell? DR BEKAII-SAAB: I’m going to leave it up to the pioneer of the regimen. DR TEMPERO: So with fixed dose-rate gemcitabine, the goal is to keep a more sustained plasma level of gemcitabine, which the drug is taken up through a nucleoside transporter in the cell membrane. And if you have a certain plasma level sustained over a long period of time, the uptake is higher with the equilibrative nuclear transporters. So the idea is basically to get more into the cell. |