In these audio proceedings from a closed Think Tank meeting held in January 2015, the invited faculty discuss and debate some of the key clinical management issues in acute and chronic leukemias and myelodysplastic syndromes. The roundtable discussion focused on actual cases managed in the practices of the faculty and recent clinical trial results factored into their decision-making. This content is available in a number of formats for listening on the go with a mobile device or in the office or at home on a computer.