Challenging Cases in Prostate Cancer: Oncologist and Nurse Investigators Consult on Actual Patients from the Practices of the Invited FacultyChallenging Cases in Prostate Cancer:
Challenging Cases in Colorectal Cancer: Oncologist and Nurse Investigators Consult on Actual Patients from the Practices of the Invited FacultyChallenging Cases in Colorectal Cancer:
ONSMM2013/VideoTARGET AUDIENCE ONSBreast2013/VideoTARGET AUDIENCE ONSLung2013/VideoTARGET AUDIENCE ONSNHL2013/VideoTARGET AUDIENCE ONSProstate2013/VideoTARGET AUDIENCE ONSCRC2013/VideoTARGET AUDIENCE Change Tx for spleen enlargement after response on Rux? Taper/stop Rux on progression after 1 y of response?Change Tx for spleen enlargement after response on Rux? Taper/stop Rux on progression after 1 y of response?A patient with myelofibrosis was started on ruxolitinib and experienced an initial improvement in symptoms and a decrease in spleen size from 18 cm to 2 cm below the costal margin (BCM). The patient now presents with an enlarged spleen at 6 cm BCM but still feels well. Should the therapy be changed? Rux dose for 65 yo, symptomatic high-risk MF, platelet count 35K/µL? Platelet count 70K/µL?Rux dose for 65 yo, symptomatic high-risk MF, platelet count 35K/µL? Platelet count 70K/µL?A 65-year-old patient with high-risk myelofibrosis, splenomegaly, normal renal function and disease-related symptomatology is being considered to receive ruxolitinib for the first time. What dose would you initiate in each of the following scenarios (or would you not use it)?
Usual Tx (+/- corticosteroids) for pts w/ asymptomatic MF but w/ anemia?Usual Tx (+/- corticosteroids) for pts w/ asymptomatic MF but w/ anemia?What treatment would you usually recommend for patients whose MF is asymptomatic but who have anemia? Initial Tx for 65 yo, int-2, sympt MF, baseline anemia? High-risk MF, anemia develops on Rux: Adjust dose?Initial Tx for 65 yo, int-2, sympt MF, baseline anemia? High-risk MF, anemia develops on Rux: Adjust dose?Which treatment would you most likely initiate for a 65-year-old patient with intermediate-2 myelofibrosis, splenomegaly and significant disease-related symptomatology who has already received EPO and danazol:
Additional CommentaryAdditional Commentary:What is the role of iron chelation for patients with MF who have frequent transfusion requirements? Additional CommentaryAdditional Commentary:How common is the occurrence of hydroxyurea-related leg ulcers?  |