Efficacy/tolerability of 2nd-line aflibercept vs bev beyond PDEfficacy/tolerability of 2nd-line aflibercept vs bev beyond PDHow would you compare the efficacy of aflibercept to the use of bevacizumab on disease progression in the second-line setting? How would you compare the side effects and tolerabilty of aflibercept to the use of bevacizumab on disease progression in the second-line setting? 60 yo with obvious progression within a few months of FOLFOX/bev?60 yo with obvious progression within a few months of FOLFOX/bev?What systemic treatment would you most likely recommend for the following patients: A 60-year-old patient with asymptomatic mCRC receives FOLFOX/bevacizumab but within a few months experiences obvious disease progression. The tumor is KRAS wild type. Same as above, but the tumor is KRAS mutant? 75 yo with slow progression 1 y after FOLFOX/bev -> 5-FU/bev?75 yo with slow progression 1 y after FOLFOX/bev -> 5-FU/bev?What systemic treatment would you most likely recommend for the following patients: 60 yo with slow progression 1 y after FOLFOX/bev -> 5-FU/bev?60 yo with slow progression 1 y after FOLFOX/bev -> 5-FU/bev?What systemic treatment would you most likely recommend for the following patients: COCCRC13/2TARGET AUDIENCE OVERVIEW OF ACTIVITY RS for 40 yo, 1.5-cm node+ (1 node) ER+ IDC? No. of MammaPrint® (70-gene signature) assays ordered in past 1 y?RS for 40-year-old, 1.5-cm node+ (1 node) ER+ IDC? No. of MammaPrint® (70-gene signature) assays ordered in past 1 y?Would you order an Oncotype DX assay for a 40-year-old premenopausal woman with a 1.5-cm, ER-positive, HER2-negative IDC and 1 positive node? Approximately how many MammaPrint® assays have you ordered in the past year? RS for 40 yo, 0.8-cm node-neg ER+ IDC? A pt w/ 3.0-cm tumor?RS for 40-year-old, 0.8-cm node-neg ER+ IDC? A pt w/ 3.0-cm tumor?Would you order an Oncotype DX assay for a 40 yo premenopausal woman with a 0.8-cm, node-negative, ER-positive, HER2-negative IDC? Would you order an Oncotype DX assay for a 40 yo premenopausal woman with a 3.0-cm, node-negative, ER-positive, HER2-negative IDC? RS for 70 yo, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj anastrozole?RS for 70-year-old, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj anastrozole?Would you order an Oncotype DX assay for a 70-year-old postmenopausal woman with a 1.5-cm, node-negative, ER-positive, HER2-negative IDC? Would you likely recommend that a 70-year-old postmenopausal woman with a 1.5-cm, node-negative IDC who received adjuvant TC and recently completed 5 years of anastrozole without problems continue or stop anastrozole therapy? Oncotype DX® Recurrence Score® (RS) for 40 yo, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj tamoxifen?Oncotype DX® Recurrence Score® (RS) for 40-year-old, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj tamoxifen?Would you likely order an Oncotype DX® assay for a 40-year-old premenopausal woman with a 1.5-cm, node-negative, ER-positive, HER2-negative IDC? RS for 40 yo, 1.5-cm node+ (1 node) ER+ IDC? No. of MammaPrint® (70-gene signature) assays ordered in past 1 y?RS for 40-year-old, 1.5-cm node+ (1 node) ER+ IDC? No. of MammaPrint® (70-gene signature) assays ordered in past 1 y?Would you order an Oncotype DX assay for a 40-year-old premenopausal woman with a 1.5-cm, ER-positive, HER2-negative IDC and 1 positive node? Approximately how many MammaPrint® assays have you ordered in the past year? RS for 40 yo, 0.8-cm node-neg ER+ IDC? A pt w/ 3.0-cm tumor?RS for 40-year-old, 0.8-cm node-neg ER+ IDC? A pt w/ 3.0-cm tumor?Would you order an Oncotype DX assay for a 40 yo premenopausal woman with a 0.8-cm, node-negative, ER-positive, HER2-negative IDC? Would you order an Oncotype DX assay for a 40 yo premenopausal woman with a 3.0-cm, node-negative, ER-positive, HER2-negative IDC? RS for 70 yo, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj anastrozole?RS for 70-year-old, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj anastrozole?Would you order an Oncotype DX assay for a 70-year-old postmenopausal woman with a 1.5-cm, node-negative, ER-positive, HER2-negative IDC? Would you likely recommend that a 70-year-old postmenopausal woman with a 1.5-cm, node-negative IDC who received adjuvant TC and recently completed 5 years of anastrozole without problems continue or stop anastrozole therapy? Oncotype DX® Recurrence Score® (RS) for 40 yo, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj tamoxifen?Oncotype DX® Recurrence Score® (RS) for 40-year-old, 1.5-cm node-neg ER+ IDC? After 5 y continue/stop adj tamoxifen?Would you likely order an Oncotype DX® assay for a 40-year-old premenopausal woman with a 1.5-cm, node-negative, ER-positive, HER2-negative IDC?  |