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Overview Matrix
Initial Tx for 65 yo, int-2, sympt MF, baseline anemia? High-risk MF, anemia develops on Rux: Adjust dose?
Usual Tx (+/- corticosteroids) for pts w/ asymptomatic MF but w/ anemia?
Rux dose for 65 yo, symptomatic high-risk MF, platelet count 35K/µL? Platelet count 70K/µL?
Change Tx for spleen enlargement after response on Rux? Taper/stop Rux on progression after 1 y of response?
Additional Commentary:
Cross-resistance between Rux and other JAK2 inhibitors?
Is hydroxyurea considered leukemogenic?
How common is the occurrence of hydroxyurea-related leg ulcers?
Role of iron chelation for pts with MF and frequent transfusions?
CME Information