ASH12 | NHL/CLL - Case 4 | Research To Practice

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ASH12 | NHL/CLL - Case 4

A 68-year-old man requiring treatment for chronic lymphocytic leukemia (CLL) (WBC = 89,000, diffuse adenopathy) comes to see you for a second opinion. His current oncologist has recommended chlorambucil, partially for economic reasons.

How would you likely counsel this patient regarding the use of up-front chlorambucil?

Chlorambucil up front is fine

Chlorambucil up front is not as effective as other treatments

Chlorambucil up front is not as effective as other treatments and less likely to control symptoms, but this is unlikely to impact overall survival

Other

What would you generally recommend for this patient?

Chlorambucil

FCR

Other chemotherapy

FR → stem cell transplant

FCR → stem cell transplant

BR → stem cell transplant

Other chemotherapy → stem cell transplant

Is there a role for R maintenance in CLL?

Yes, commonly

Yes, occasionally

Not enough information to comment

Have you utilized lenalidomide outside of a protocol setting in the management of CLL?

No, because of reimbursement issues

No, but I would in the right situation

Yes

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