Welcome to the video proceedings from this unique event.

Over the past several years, as our understanding of the pathophysiology and biology of cancer development and growth has rapidly expanded, we have witnessed a dramatic shift in focus away from a traditional chemotherapeutic and radiotherapeutic treatment paradigm toward a disease management model centered on exploiting and disrupting the unique molecular pathways responsible for cancer cell proliferation, survival and metastasis. This monumental change in approach has resulted in the development of a litany of novel biologic and molecularly targeted agents with efficacy across numerous tumor types and distinct mechanisms of action, tolerability considerations and individualized patient applications.

Although the introduction of these new biologic therapies has provided substantial benefits to many cancer patients, it has also created a number of areas of controversy and confusion for clinicians. To that end, this unique event was designed to bring together clinical investigators with expertise across the oncology disease spectrum to examine common trends, themes and lessons learned through their extensive involvement in the clinical development of novel compounds. By providing an open discussion forum focused on this compelling subject matter, this meeting presented an array of theoretical and practical concepts relevant to the practicing oncologist. As such, the recorded proceedings represent a valuable and convenient means by which to gain perspectives and a deeper understanding of how current paradigms affect future research and current clinical care.

Neil Love, MD

FACULTY AFFILIATIONS
	MODERATOR Neil Love, MD Editor, Cancer Update Audio Series Research To Practice Miami, Florida		Gregory J Riely, MD, PhD Assistant Attending Memorial Sloan-Kettering Cancer Center New York, New York
	Nicholas J Vogelzang, MD Director and Executive Vice President for Academic Affairs Nevada Cancer Institute Las Vegas Professor of Medicine University of Nevada School of Medicine Las Vegas, Nevada		Alan P Venook, MD Professor of Clinical Medicine University of California San Francisco San Francisco, California
	Mario E Lacouture, MD Director, SERIES Clinic Assistant Professor Department of Dermatology Robert H Lurie Comprehensive Cancer Center Northwestern University Chicago, Illinois		George W Sledge Jr, MD Ballve-Lantero Professor of Oncology Professor of Medicine and Pathology Melvin and Bren Simon Indiana University Cancer Center Indianapolis, Indiana
	Ronald B Natale, MD Medical Oncologist, Cedars-Sinai Outpatient Cancer Center Senior Research Advisor and Director, National Lung Cancer Research Program Aptium Oncology Inc Los Angeles, California		Patricia M LoRusso, DO Director, Phase I Service Karmanos Cancer Institute Professor of Medicine Wayne State University Detroit, Michigan