TARGET AUDIENCE
This program is intended for medical oncologists, hematology-oncology fellows and other allied healthcare professionals involved in the treatment of non-small cell lung cancer (NSCLC).

OVERVIEW OF ACTIVITY
Lung cancer is a devastating disease with a broad impact on public health: In the year 2017 it is estimated that 222,500 individuals will be diagnosed and 155,870 will die of the disease in the United States alone. A major focus of recent lung cancer research has been the development of molecular-targeted agents and the identification of biomarkers to help guide treatment selection for individuals who harbor specific oncogenic alterations. This and a number of subsequent drug approvals have created a paradigm shift in the way patients with advanced NSCLC are initially stratified and counseled, moving from a “one-size-fits-all” approach to a customized, biomarker-driven treatment algorithm. In addition, deeper insights into how to harness the body’s immune system are now being applied to the management of this lethal disease, stemming from an improved understanding of the mechanism of tumor immune response and its evasion by certain cancers. The advent of these treatment options presents new promise of efficacy and safety for patients with lung cancer but also poses a challenge to oncologists and their support staff in appropriately selecting individuals who may benefit from specific agents and in determining how to integrate these therapies into standard treatment algorithms.

These video proceedings from a CME symposium held during the 2017 ASCO Annual Meeting feature renowned lung cancer clinical investigators weighing in on challenging questions and cases from a panel of community-based general oncologists and reviewing relevant data. By providing information on the latest research developments and their potential application to routine practice, this activity is designed not only to improve clinicians’ knowledge of the rapidly evolving oncology treatment landscape but also to provide them with practical perspectives to help them become better and more effective caregivers.

LEARNING OBJECTIVES

• Design evidence-based strategies for the management of localized and locally advanced NSCLC, considering the potential contributions of systemic and local therapeutic modalities.
• Compare and contrast expert perspectives on the indications for mutation and/or PD-L1 analysis for patients with localized and metastatic NSCLC, and, when appropriate, use validated testing platforms to obtain this information.
• Review recent FDA approvals and available research data documenting the safety and efficacy of pembrolizumab alone or in combination with carboplatin/pemetrexed for patients with previously untreated metastatic NSCLC, and use this information to appropriately integrate the use of pembrolizumab into this setting.
• Consider age, performance status and other patient- or disease-related factors to guide the selection of first-line therapy for patients with newly diagnosed metastatic squamous and nonsquamous NSCLC without an identifiable driver mutation.
• Appreciate available clinical trial data documenting the efficacy of necitumumab and ramucirumab in metastatic NSCLC, and discern how these agents can be optimally integrated into clinical practice for patients with PD-L1-positive and PD-L1-negative squamous and nonsquamous disease.
• Educate patients about the side effects associated with recently approved novel agents and immunotherapeutic approaches, and provide preventive strategies to reduce or ameliorate these toxicities.
• Consider published safety and efficacy data with available and emerging targeted therapeutic strategies, and appropriately incorporate these therapies into the care of patients with identified tumor driver mutations or alterations.
• Recall the scientific rationale for ongoing investigation of novel agents or therapeutic approaches in NSCLC, and counsel appropriately selected patients about study participation.

ACCREDITATION STATEMENT
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT
CME credit is no longer available for this issue

AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
CME credit is no longer available for this issue

HOW TO USE THIS CME ACTIVITY
This CME activity consists of a video component.
CME credit is no longer available for this issue

CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

Ramaswamy Govindan, MD
Professor of Medicine
Co-Director, Section of Medical Oncology
Division of Oncology
Washington University School of Medicine
St Louis, Missouri

Advisory Committee: AbbVie Inc, Ariad Pharmaceuticals Inc, AstraZeneca Pharmaceuticals LP, Baxalta Inc, INC Research, Roche Laboratories Inc; Consulting Agreements: AbbVie Inc, Ariad Pharmaceuticals Inc, Astellas Pharma Global Development Inc, Baxalta Inc, Bristol-Myers Squibb Company, Genentech BioOncology, INC Research; Contracted Research and Speakers Bureau: AbbVie Inc, Ariad Pharmaceuticals Inc, Baxalta Inc, INC Research.

Leora Horn, MD, MSc
Associate Professor of Medicine
Clinical Director, Thoracic Oncology Research Program
Assistant Vice Chairman for Faculty Development
Vanderbilt University Medical Center
Nashville, Tennessee

Advisory Committee: Celgene Corporation, Genentech BioOncology, Lilly, Merck; Consulting Agreements: Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Xcovery; Other Remunerated Activities: EMD Serono Inc.

Corey J Langer, MD
Director of Thoracic Oncology
Abramson Cancer Center
Professor of Medicine
Perelman School of Medicine
University of Pennsylvania
Vice Chair, Radiation Therapy Oncology Group
Philadelphia, Pennsylvania

Advisory Committee: Abbott Laboratories, AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim Pharmaceuticals Inc, Celgene Corporation, Genentech BioOncology, Lilly, Merck, Pfizer Inc, Roche Laboratories Inc, Takeda Oncology; Consulting Agreements: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Eisai Inc, Genentech BioOncology, Lilly, Merck, Novartis, Pfizer Inc, Roche Laboratories Inc, Takeda Oncology; Contracted Research: Advantagene Inc, Ariad Pharmaceuticals Inc, GlaxoSmithKline, Inovio Pharmaceuticals Inc, Merck, Takeda Oncology; Data and Safety Monitoring Board: Amgen Inc.

Gregory J Riely, MD, PhD
Associate Attending
Memorial Sloan Kettering Cancer Center
New York, New York

Consulting Agreement: Genentech BioOncology; Contracted Research: Ariad Pharmaceuticals Inc, Astellas Pharma Global Development Inc, Novartis, Pfizer Inc.

Jean-Charles Soria, MD, PhD
Full Professor, Paris University XI
Head of Drug Development Department
Institut Gustave Roussy
Villejuif, France

Honoraria: Astex Pharmaceuticals, AstraZeneca Pharmaceuticals LP, GamaMabs Pharma, GlaxoSmithKline, Lilly, Merus BV, MSD, Pfizer Inc, Pharma Mar SA, Pierre Fabre, Roche Laboratories Inc, Sanofi Genzyme, Servier, Takeda Oncology, Symphogen A/S.

MODERATOR AND CO-CHAIR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Baxalta Inc, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Pharma Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, CTI BioPharma Corp, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Medivation Inc, a Pfizer Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, NanoString Technologies, Natera Inc, Novartis, Novocure, Onyx Pharmaceuticals, an Amgen subsidiary, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sanofi Genzyme, Seattle Genetics, Sigma-Tau Pharmaceuticals Inc, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro Inc, Teva Oncology and Tokai Pharmaceuticals Inc.

RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no relevant conflicts of interest to disclose.

This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantor.

This activity is supported by an educational grant from Lilly.

Hardware/Software Requirements:
A high-speed Internet connection
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
Adobe Flash Player 10.2 plug-in or later
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio

Last review date: August 2017
Expiration date: August 2018