Oncology Grand Rounds: Part 6 — Breast Cancer

Video proceedings from the sixth in a series of 6 integrated symposia held at the 2018 ONS Annual Congress. Featuring perspectives from Dr Lisa A Carey, Ms Lauren Czapla, Dr Sara A Hurvitz and Ms Madelaine C Kuiper.

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Introduction
Program Overview: Dr Love
HER2-Positive Localized Breast Cancer
Case (Ms Czapla): A 35-year-old woman with ER-negative, HER2-positive inflammatory breast cancer who received neoadjuvant paclitaxel, trastuzumab and pertuzumab
HER2-Positive Metastatic Disease
Case (Ms Kuiper): A 48-year-old woman with ER-positive, HER2-positive metastatic breast cancer who received multiple lines of HER2-targeted therapy
ER-Positive, HER2-Negative Metastatic Disease
Case (Ms Kuiper): A 60-year-old woman who presented with de novo ER-positive, HER2-negative metastatic lobular carcinoma and received ribociclib/letrozole
Case (Ms Czapla): A 36-year-old woman with ER-positive, HER2-negative metastatic breast cancer who was originally diagnosed with localized disease while 28 weeks pregnant
Case (Ms Kuiper): A 41-year-old woman who has received multiple lines of systemic therapy for ER-positive, HER2-negative metastatic breast cancer, including mostly recently everolimus and tamoxifen
Triple-Negative Metastatic Disease
Case (Ms Czapla): A 73-year-old woman with triple-negative metastatic breast cancer who experienced a prolonged response to pembrolizumab