There is no registration fee for this event. However, preregistration is advised as seating is limited for the in-person meeting in Charlotte. See LOCATION tab for instructions on how to secure hotel accommodations.  

This activity is supported by educational grants from AbbVie inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Daiichi Sankyo Inc, Eisai Inc, Gilead Sciences Inc, ImmunoGen Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Karyopharm Therapeutics, Lilly, Merck, Mersana Therapeutics Inc, Pharmacyclics LLC, an AbbVie Company and Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, and Seagen Inc.

Target Audience
This live activity has been designed to meet the educational needs of medical oncologists, hematologists, hematology-oncology fellows, nurse practitioners, clinical nurse specialists and other allied cancer professionals involved in the treatment of cancer.

Learning Objectives

BREAST CANCER

• Assess published research to guide the selection and duration of neoadjuvant, adjuvant and extended-adjuvant therapy for patients with HER2-overexpressing localized breast cancer.
• Evaluate the results of genomic assays and other patient- and treatment-related factors to personalize adjuvant systemic therapy for newly diagnosed ER-positive breast cancer.
• Consider available clinical trial findings with CDK4/6 inhibitors for localized ER-positive, HER2-negative breast cancer, and assess the optimal role of these agents as neoadjuvant or adjuvant treatment.
• Appreciate available Phase III data documenting the efficacy of adjuvant PARP inhibition for high-risk HER2-negative localized breast cancer with a BRCA mutation, and consider the role of this strategy in clinical practice.
• Review published data demonstrating the benefit of chemotherapy in combination with anti-PD-1/PD-L1 antibodies for localized triple-negative breast cancer (TNBC), and use this information to make appropriate treatment recommendations.
• Implement a long-term clinical plan for the management of HER2-positive metastatic breast cancer (mBC), incorporating established and recently approved anti-HER2 therapies.
• Individualize the selection and sequencing of systemic therapy for patients with ER-positive mBC, considering age, menopausal status, prior treatment course, PIK3CA mutation status, level of HER2 expression, comorbidities, symptomatology and extent and sites of disease.
• Evaluate published research findings guiding the selection and sequencing of available therapeutic agents for metastatic TNBC.
• Appraise published efficacy and safety data with PARP inhibitors for patients with mBC harboring BRCA1/2 mutations, and consider the diagnostic and therapeutic implications for nonresearch care.
• Recall the mechanisms of action of, early data with and ongoing clinical trials evaluating other novel agents and treatment strategies under development for localized and metastatic breast cancer.

GASTROINTESTINAL CANCERS

• Optimize the use of adjuvant chemotherapy for localized colorectal cancer (CRC), considering various clinical and biologic factors such as patient age, performance status, disease stage, et cetera.
• Develop a long-term care plan for metastatic CRC, considering the patient’s biomarker profile, tumor location, prior systemic therapy, symptomatology and personal goals of treatment.
• Use HER2 status, PD-L1 combined positive score and other clinical and biologic factors to optimize the selection and sequencing of systemic therapy for patients with gastric, gastroesophageal junction and esophageal cancers.
• Consider age, performance status, degree of liver function and other clinical factors in the selection of first- and later-line therapy for patients with unresectable or metastatic hepatocellular carcinoma.
• Evaluate available data documenting the efficacy and safety of anti-PD-L1 antibody therapy in combination with chemotherapy as first-line treatment for advanced biliary tract cancers (BTCs), and consider the role of this therapeutic strategy.
• Recognize the molecular heterogeneity of cholangiocarcinoma and other BTCs, and appreciate the biologic rationale for efforts to exploit documented abnormalities in patients with these diseases.
• Recall clinical trial data with approved and investigational systemic interventions for metastatic pancreatic adenocarcinoma, and establish an evidence-based approach to selection of therapy for patients.
• Appraise available and emerging data with investigational agents currently in clinical testing for gastrointestinal cancers, and as applicable, refer eligible patients for clinical trial participation.

GENITOURINARY CANCERS

• Evaluate the published research database supporting the use of secondary hormonal agents in the management of nonmetastatic castration-sensitive and castration-resistant prostate cancer, and apply this information in the discussion of nonresearch treatment options.
• Explore available data with cytotoxic and secondary hormonal therapy or combinations of these approaches for metastatic hormone-sensitive prostate cancer to design effective treatment plans for patients.
• Establish an evidence-based approach to the selection and sequencing of therapeutic options for patients with metastatic castration-resistant prostate cancer (mCRPC), considering age, comorbidities, prior therapeutic exposure and other factors.
• Assess available and emerging research supporting the use of PARP inhibitors for mCRPC, and discern how to optimally incorporate these agents into current and future clinical management algorithms.
• Review available clinical trial evidence with immune checkpoint inhibitors as monotherapy or as maintenance after platinum-based chemotherapy in the treatment of newly diagnosed metastatic urothelial bladder cancer (UBC), and determine the current utility of these agents in clinical practice.
• Recall pivotal clinical trial findings leading to the FDA approval of novel compounds with unique mechanisms of action for previously treated locally advanced or metastatic UBC, and identify patients for whom these agents would be appropriate.
• Apply research findings and other clinical and biologic factors in the best-practice selection of first-line therapy for metastatic renal cell carcinoma (mRCC).
• Develop a rational approach to the selection and sequencing of systemic therapies for patients with mRCC who experience disease progression on first-line treatment.
• Consider available data supporting the use of anti-PD-1 antibody therapy for nonmetastatic UBC or RCC, and determine how this strategy can be appropriately integrated into patient care.
• Reflect on available and emerging data with investigational agents and strategies currently in testing for prostate cancer, UBC and RCC, and as applicable, refer eligible patients for clinical trial participation.

CHRONIC LYMPHOCYTIC LEUKEMIA AND LYMPHOMAS

• Individualize the selection and sequencing of systemic therapy for patients with newly diagnosed or relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), considering clinical presentation, age, performance status (PS), biomarker profile and coexisting medical conditions.
• Understand published research data informing the selection, sequencing or combining of available therapeutic agents in the nonresearch care of patients with previously untreated or R/R follicular lymphoma (FL).
• Recognize the mechanisms of action and the efficacy and safety of approved and investigational agents for diffuse large B-cell lymphoma (DLBCL) to determine the current and potential utility of those agents in clinical practice.
• Consider patient age, PS and other clinical and biologic factors in the up-front and subsequent treatment of mantle cell lymphoma (MCL).
• Incorporate available and emerging therapeutic strategies into the best-practice management of newly diagnosed and R/R Hodgkin lymphoma.
• Assess available clinical trial findings informing the use of CD19-directed CAR (chimeric antigen receptor) T-cell therapy for R/R DLBCL, MCL or FL, and counsel appropriately selected patients regarding the potential benefits of this strategy.
• Recall new data with agents and strategies currently under investigation for CLL and various lymphoma subtypes, and discuss ongoing trial opportunities with eligible patients.

GYNECOLOGIC CANCERS

• Assess available clinical trial data with and approved indications for FDA-endorsed PARP inhibitors for newly diagnosed and recurrent ovarian cancer (OC) to optimally incorporate these agents into patient care.
• Appreciate the biologic rationale for and published trial data with the combination of PARP inhibitors with other systemic therapies, and consider the implications for current and future OC management and research.
• Recognize the rationale for targeting folate receptor alpha in OC, and determine optimal testing methods and the current role of novel approaches to therapeutically exploit this newly relevant biomarker.
• Review the benefits observed with anti-PD-1/PD-L1 antibodies for advanced microsatellite instability-high or mismatch repair-deficient endometrial cancer (EC), and appropriately integrate these agents into patient care.
• Consider the biologic rationale for and available data with the combination of anti-PD-1/PD-L1 antibodies with agents targeting the VEGF pathway, and select patients with metastatic EC for this novel therapeutic approach.
• Interrogate published efficacy and safety findings with anti-PD-1 antibodies as monotherapy or in combination with chemotherapy for metastatic cervical cancer (CC), and consider the current and potential role of immune checkpoint inhibition in therapy for this disease.
• Recognize the incidence of tissue factor expression in patients with CC, and evaluate the current and future roles of novel agents designed to exploit this therapeutic target.
• Reflect on investigational agents and strategies currently in testing for OC, EC and CC, and as applicable, refer eligible patients for clinical trial participation.

LUNG CANCER

• Evaluate available and emerging data documenting the efficacy and safety of anti-PD-1/PD-L1 antibody-based approaches as neoadjuvant, adjuvant or consolidation therapy for patients with nonmetastatic non-small cell lung cancer (NSCLC).
• Acknowledge the FDA approval of adjuvant EGFR tyrosine kinase inhibitor therapy for patients with localized NSCLC with EGFR mutations, and identify those for whom treatment with this approach would be warranted.
• Counsel patients with metastatic NSCLC with EGFR mutations regarding available therapeutic considerations, explaining the relevance of mutation type, symptomatology, sites and extent of metastases and other factors.
• Understand the biology of EGFR exon 20 insertion mutations, and evaluate how recently approved agents should be employed in the care of patients with these abnormalities.
• Assess the efficacy and safety of commercially available and investigational agents for patients with metastatic NSCLC with an ALK or ROS1 rearrangement, and use this information to select first- and later-line therapy.
• Recall published and emerging data with commercially available and experimental agents exploiting other oncogenic pathways (ie, RET, MET, HER2, KRAS G12C) mediating the pathogenesis of tumors in unique patient subsets.
• Review recent therapeutic advances related to anti-PD-1/PD-L1 antibodies as monotherapy or in combination with chemotherapy, chemobiologic therapy or anti-CTLA-4 antibodies for metastatic NSCLC, and discern how these approaches can be optimally employed in the management of this disease.
• Develop a long-term care plan, including the option of clinical trial participation, for patients with progressive NSCLC, considering prior systemic therapy, symptomatology, performance status and personal goals of treatment.
• Reflect on investigational agents and strategies currently in testing for lung cancer, and as applicable, refer eligible patients for clinical trial participation.

Accreditation Statements
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Research To Practice is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation (ANCC).

CME Credit Designation Statements
Research To Practice designates this live activity for a maximum of 6 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CME and ABIM MOC credit form links will be emailed to each participant within 3 to 5 business days of the activity.

NCPD Credit Designation Statements
This educational activity for 6 contact hours is provided by Research To Practice.

This activity is awarded 6 ANCC pharmacotherapeutic contact hours.

To obtain a certificate of completion and receive credit for this event, nurses must return a completed Educational Assessment and Credit Form for the modules they attend. The credit form links will be emailed to participants within 3 to 5 business days of the activity.

American Board of Internal Medicine (ABIM) — Maintenance of Certification (MOC)
Successful completion of this CME activity, which includes participation in the evaluation component and a short post-test, enables the participant to earn up to 6 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Please note, this program has been specifically designed for the following ABIM specialties: medical oncology and hematology.

Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information. For those clinicians wishing to receive ABIM MOC credit for attending, you will receive an email after the event with instructions.

Oncology Nursing Certification Corporation (ONCC)/Individual Learning Needs Assessment (ILNA) Certification Information
This activity will be submitted to the ONCC for ILNA verification.

Unlabeled/Unapproved Uses Notice
There is no implied or real endorsement of any product by Research To Practice, ACCME or the ANCC. Any off-label use as declared by the FDA will be identified.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — Dr Burstein has no relevant conflicts of interest to disclose. The following faculty reported relevant financial relationships with ineligible entities:

Dr Bekaii-Saab — Consulting Agreements (to Institution): Arcus Biosciences, Bayer HealthCare Pharmaceuticals, Eisai Inc, Genentech, a member of the Roche Group, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Merck, Merck KgaA, Merus BV, Pfizer Inc, Seagen Inc; Consulting Agreements (to Self): AbbVie Inc, Aptitude Health, AstraZeneca Pharmaceuticals LP, BeiGene Ltd, Boehringer Ingelheim Pharmaceuticals Inc, Caladrius Biosciences, Celularity, Daiichi Sankyo Inc, Deciphera Pharmaceuticals Inc, Exact Sciences Corporation, Foundation Medicine, Illumina, Janssen Biotech Inc, Kanaph Therapeutics, Natera Inc, Sanofi, Sobi, Stemline Therapeutics Inc, Treos Bio Ltd, Zai Lab; Data and Safety Monitoring Board/Committee: 1Globe Health Institute, AstraZeneca Pharmaceuticals LP, Eisai Inc, Exelixis Inc, FibroGen Inc, Merck, Suzhou Kintor; Inventions/Patents: WO/2018/183488 licensed to Imugene, WO/2019/055687 licensed to Recursion; Research Funding (to Institution): AbGenomics, Agios Pharmaceuticals Inc, Arcus Biosciences, Arrys Therapeutics, a wholly owned subsidiary of Kyn Therapeutics, Atreca, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Eisai Inc, Genentech, a member of the Roche Group, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Lilly, Merus BV, Mirati Therapeutics Inc, Novartis, Pfizer Inc, Seagen Inc, Sumitomo Dainippon Pharma Oncology Inc; Scientific Advisory Board: Artiva Biotherapeutics Inc, Immuneering Corporation, Imugene, Panbela Therapeutics Inc, Replimune, Xilis; Nonrelevant Financial Relationship: MJH Life Sciences, Pancreatic Cancer Action Network, UptoDate. Dr Birrer — Advisory Board: AstraZeneca Pharmaceuticals LP, GSK, Mersana Therapeutics Inc. Dr Brander — Advisory Committee: AbbVie Inc, Genentech, a member of the Roche Group, Pfizer Inc, TG Therapeutics Inc; Consulting Agreements: AbbVie Inc, Genentech, a member of the Roche Group, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company; Contracted Research: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, ArQule Inc, Ascentage Pharma, AstraZeneca Pharmaceuticals LP, BeiGene Ltd, Bristol-Myers Squibb Company, Catapult Therapeutics, CATO SMS, Celgene Corporation, DTRM Biopharma Co Ltd, Genentech, a member of the Roche Group, Juno Therapeutics, a Celgene Company, MEI Pharma Inc, Newave Pharmaceutical Inc, Novartis, Pharmacyclics LLC, an AbbVie Company, TG Therapeutics Inc; Nonrelevant Financial Relationship: CLL Society (expert medical council), NCCN (panel member). Dr Dagogo-Jack — Consulting Fees: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals Inc, BostonGene, Bristol-Myers Squibb Company, Catalyst Pharmaceuticals, Genentech, a member of the Roche Group, Janssen Biotech Inc, Novocure Inc, Pfizer Inc, Sanofi, Syros Pharmaceuticals Inc, Xcovery; Honoraria: Aptitude Health, DAVA Oncology, Foundation Medicine; Research Support: Array BioPharma Inc, a subsidiary of Pfizer Inc, BostonGene, Genentech, a member of the Roche Group, Guardant Health, Novartis, Pfizer Inc; Nonrelevant Financial Relationship: American Lung Association, ASCO Post, Creative Educational Concepts LLC, Medscape, OncLive, Total Health Conferencing, Triptych Health Partners. Dr Kaklamani — Consulting Agreements: AstraZeneca Pharmaceuticals LP, Gilead Sciences Inc, Puma Biotechnology Inc, TerSera Therapeutics LLC; Contracted Research: Eisai Inc; Data and Safety Monitoring Board/Committee: Bristol-Myers Squibb Company; Speakers Bureau: AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Exact Sciences Corporation, Genentech, a member of the Roche Group, Gilead Sciences Inc, Novartis, Pfizer Inc, Seagen Inc. Dr Liu — Advisory Committee: AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Eisai Inc, Elevation Oncology, Genentech, a member of the Roche Group, Gilead Sciences Inc, Guardant Health, Janssen Biotech Inc, Jazz Pharmaceuticals Inc, Novartis, Regeneron Pharmaceuticals Inc, Sanofi, Takeda Pharmaceuticals USA Inc; Consulting Agreements: AstraZeneca Pharmaceuticals LP, Catalyst Pharmaceuticals, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology, Genentech, a member of the Roche Group, Janssen Biotech Inc, Jazz Pharmaceuticals Inc, Merck Sharp & Dohme LLC, Novartis, Regeneron Pharmaceuticals Inc, Sanofi, Takeda Pharmaceuticals USA Inc, Turning Point Therapeutics Inc; Contracted Research: Alkermes, Bristol-Myers Squibb Company, Elevation Oncology, Genentech, a member of the Roche Group, Gilead Sciences Inc, Merck, Merus BV, Nuvalent, Pfizer Inc, RAPT Therapeutics, Turning Point Therapeutics Inc; Data and Safety Monitoring Board/Committee: Candel Therapeutics. Dr Matulonis — Advisory Committee: Allarity Therapeutics, ImmunoGen Inc, NextCure; Consulting Agreements: Agenus Inc, AstraZeneca Pharmaceuticals LP, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, CureLab Oncology, GSK, Merck, MorphoSys, Novartis, Trillium Therapeutics Inc; Data and Safety Monitoring Board/Committee: Alkermes, Symphogen A/S; Nonrelevant Financial Relationship: Clearity, Med Learning Group, Ovarian Cancer Research Alliance, Rivkin Foundation. Dr Mehta — Advisory Committee: Astellas, BostonGene, Bristol-Myers Squibb Company, Guardant Health, Lilly, Novartis, Seagen Inc; Consulting Agreements: Astellas, Lilly; Speakers Bureau: Daiichi Sankyo Inc, Natera Inc. Dr Moskowitz — Research Support: ADC Therapeutics, BeiGene Ltd, Incyte Corporation, Merck, Seagen Inc; Scientific Advisory Board: ADC Therapeutics, Incyte Corporation, Kite, A Gilead Company. Dr Petrylak — Consulting Agreements: Advanced Accelerator Applications, Amgen Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bicycle Therapeutics, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Clovis Oncology, Exelixis Inc, Gilead Sciences Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, Lilly, Merck, Mirati Therapeutics Inc, Monopteros Therapeutics, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Regeneron Pharmaceuticals Inc, Roche Laboratories Inc, Sanofi, Seagen Inc, UroGen Pharma; Contracted Research: Advanced Accelerator Applications, Agensys Inc, Arvinas, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, BioXcel Therapeutics, Bristol-Myers Squibb Company, Clovis Oncology, Daiichi Sankyo Inc, Eisai Inc, Endocyte Inc, Ferring Pharmaceuticals, Genentech, a member of the Roche Group, Gilead Sciences Inc, Innocrin Pharmaceuticals Inc, Lilly, Medivation Inc, a Pfizer Company, Merck, Mirati Therapeutics Inc, Novartis, Pfizer Inc, Progenics Pharmaceuticals Inc, Replimune, Roche Laboratories Inc, Sanofi, Seagen Inc. Dr Srinivas — Advisory Committee: Bayer HealthCare Pharmaceuticals, Janssen Biotech Inc, Merck, Novartis; Contracted Research: Bayer HealthCare Pharmaceuticals, Merck, Novartis; Data and Safety Monitoring Board/Committee: Pfizer Inc.

MODERATORS — Suzanne R Fanning, DO — No relevant conflicts of interest to disclose. Justin Peter Favaro, MD, PhD — Advisory Board: Genzyme Corporation, Fresenius, Labcorp. Kellie E Schneider, MD — No relevant conflicts of interest to disclose. Nasfat Shehadeh, MD — No relevant conflicts of interest to disclose.

Research To Practice CME/NCPD Planning Committee Members, Staff and Reviewers — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

Supporters
This activity is supported by educational grants from AbbVie inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Daiichi Sankyo Inc, Eisai Inc, Gilead Sciences Inc, ImmunoGen Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Karyopharm Therapeutics, Lilly, Merck, Mersana Therapeutics Inc, Pharmacyclics LLC, an AbbVie Company and Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, and Seagen Inc.

Location
Charlotte Convention Center
501 S College Street
Charlotte, NC 28202
Phone: (704) 339-6000

Meeting Room
Room 207 (West Wing) – 2^nd Floor

Hotel Accommodations
To secure hotel accommodations, please contact the Westin Charlotte hotel (601 S College St, Charlotte, NC 28202) at (704) 375-2600 and mention you are attending the NCOA/SCOS partner meeting in order to secure the best available rate.

Directions
There is a connecting walkway located at the backside of the Westin Charlotte hotel that goes to the Charlotte Convention Center. For those driving, best parking option for the convention center is the Nascar Hall of Fame parking garage located on 500 S Brevard Street.