Friday, December 9, 2022, 11:30 AM – 1:30 PM CT (12:30 PM – 2:30 PM ET) – New Orleans, Louisiana

Addressing Current Questions and Controversies in the Management of Chronic Lymphocytic Leukemia — What Clinicians Want to Know (Part 1 of a 3-Part Series)

A CME Friday Satellite Symposium and Virtual Event Preceding the 64th ASH Annual Meeting

Hyatt Regency New Orleans
601 Loyola Avenue
New Orleans, LA 70113
Hotel Phone: (504) 561-1234

Program Schedule — Central Time
11:00 AM – 11:30 AM — Registration and Lunch
11:30 AM – 1:30 PM — Educational Meeting

Meeting Room
Celestin Ballroom ABCD (Level 3)

This event will also be webcast live.
Please see Registration tab for details.
There is no registration fee for this event. For the in-person symposium in New Orleans, preregistration is required as seating is limited.  
Alexey V Danilov, MD, PhD
Professor, Department of Hematology and Transplantation
Co-Director, Toni Stephenson Lymphoma Center
City of Hope National Medical Center
Duarte, California

Matthew S Davids, MD, MMSc
Associate Professor of Medicine
Harvard Medical School
Director of Clinical Research
Division of Lymphoma
Dana-Farber Cancer Institute
Boston, Massachusetts

Professor Dr Arnon P Kater, MD, PhD
Dept of Hematology, Cancer Center
Amsterdam University Medical Centers
University of Amsterdam
Amsterdam, Netherlands

Lindsey Roeker, MD
Assistant Attending L1
Memorial Sloan Kettering Cancer Center
New York, New York

Philip A Thompson, MB, BS
Associate Professor, Department of Leukemia
Division of Cancer Medicine
The University of Texas
MD Anderson Cancer Center
Houston, Texas

Neil Love, MD
Research To Practice
Miami, Florida

This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, BeiGene Ltd, Genentech, a member of the Roche Group, Lilly, Pharmacyclics LLC, an AbbVie Company and Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC.
Program Schedule — Central Time
11:00 AM – 11:30 AM — Registration and Lunch Buffet
11:30 AM – 1:30 PM — Educational Meeting

MODULE 1: Front-Line Treatment for Chronic Lymphocytic Leukemia (CLL)

  • Clinical, biologic and practical factors in the selection of first-line treatment for patients with CLL requiring active therapy
  • Long-term findings from Phase III studies assessing ibrutinib- and acalabrutinib-based therapy for treatment-naïve CLL
  • Available results from the Phase III SEQUOIA trial comparing zanubrutinib to bendamustine/rituximab as first-line therapy for previously untreated CLL
  • Outcomes observed with venetoclax-based up-front regimens for older/unfit and fit patients with treatment-naïve CLL; implications of the GAIA (CLL13) study results for selection of an anti-CD20 antibody partner
  • Importance, if any, of minimal residual disease (MRD) assessment in determining the duration of venetoclax-based up-front therapy; current and future role of MRD in clinical decision-making

MODULE 2: Novel Strategies Combining Bruton Tyrosine Kinase (BTK) and Bcl-2 Inhibitors for CLL

  • Mechanistic rationale for combining BTK inhibitors, Bcl-2 inhibitors and/or anti-CD20 antibodies in the management of CLL
  • Efficacy outcomes from early-phase studies evaluating ibrutinib in combination with venetoclax for treatment-naïve and relapsed/refractory (R/R) CLL
  • Design, eligibility criteria and major efficacy and safety findings from the Phase III GLOW trial evaluating ibrutinib/venetoclax versus chlorambucil/obinutuzumab in the first-line treatment of CLL
  • Outcomes reported in available data sets investigating acalabrutinib or zanubrutinib in combination with venetoclax, with or without an anti-CD20 antibody
  • Ongoing Phase III studies assessing novel doublet and triplet combinations for previously untreated and R/R disease

MODULE 3: Optimal Management of Adverse Events with BTK and Bcl-2 Inhibitors; Considerations for Special Patient Populations

  • Importance of underlying comorbidities (eg, hypertension, chronic kidney or liver disease, atrial fibrillation, GERD) in clinical decision-making for patients with CLL
  • Incidence of side effects (eg, hemorrhage, atrial fibrillation, infections, cytopenias, hypertension, headache) with ibrutinib, acalabrutinib and zanubrutinib in published clinical trials
  • Implications for clinical decision-making of results from the Phase III ELEVATE-RR and ALPINE studies evaluating acalabrutinib and zanubrutinib, respectively, versus ibrutinib for previously treated disease
  • Pharmacokinetics, pharmacodynamics and safety of the maleate tablet formulation of acalabrutinib compared to standard capsules; potential role in therapy for patients receiving proton pump inhibitors or those with difficulty swallowing
  • Frequency of tumor lysis syndrome and other adverse events with venetoclax therapy in CLL clinical trials; recommended protocols for monitoring, prevention and management
  • Incidence and severity of clinically relevant toxicities encountered when combining BTK and Bcl-2 inhibitors with or without anti-CD20 antibodies

MODULE 4: Selection and Sequencing of Available Therapies for R/R Disease

  • Key factors in selecting therapy for patients who experience disease progression on first-line treatment
  • Long-term follow-up from Phase III trials evaluating BTK and Bcl-2 inhibitors for R/R CLL
  • Published data sets and ongoing studies exploring the role of rechallenge with an agent or class of agents received in a prior line of therapy
  • Available data with and clinical role of PI3 kinase inhibitors in CLL management
  • Current clinical utility of chemoimmunotherapy in the treatment of CLL

MODULE 5: Promising Investigational Agents and Strategies

  • Pharmacologic similarities and differences between the investigational noncovalent BTK inhibitor pirtobrutinib and covalent BTK inhibitors; implications for efficacy and tolerability
  • Updated results among patients with R/R CLL in the BRUIN study of pirtobrutinib; potential clinical application
  • Biologic rationale for the investigation of CD19-directed chimeric antigen receptor (CAR) T-cell therapy for R/R CLL
  • Key findings from the lisocabtagene maraleucel (liso-cel) monotherapy and the liso-cel/ibrutinib cohorts of the TRANSCEND CLL 004 trial
  • Clinical and research implications of recent reports indicating long-term sustained remissions with functional persistence of CAR T cells after CAR T-cell therapy in patients with CLL
  • Other promising agents and strategies under investigation for CLL

Target Audience
This activity is intended for hematologists, medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of chronic lymphocytic leukemia.

Learning Objectives
Upon completion of this activity, participants should be able to

  • Individualize the selection of systemic therapy for newly diagnosed chronic lymphocytic leukemia (CLL), considering new research findings, clinical presentation, biomarker profile, coexisting medical conditions and patient preferences.
  • Appraise available Phase III data documenting the comparative efficacy and tolerability of first- and second-generation Bruton tyrosine kinase (BTK) inhibitors, and consider the implications of these findings for clinical decision-making for patients with newly diagnosed or previously treated CLL.
  • Appreciate the scientific rationale for the investigation of combined BTK and Bcl-2 inhibition, and review recently presented data documenting the safety and efficacy of this strategy for newly diagnosed CLL.
  • Analyze how patient age, performance status, prior therapeutic exposure and other biologic and disease-related factors affect the selection and sequencing of therapy for relapsed/refractory (R/R) CLL.
  • Implement a plan of care to recognize and manage side effects and toxicities associated with recently approved and emerging systemic therapies for CLL.
  • Discuss available clinical research demonstrating the efficacy and safety of noncovalent BTK inhibitors in patients with CLL, and use this information to evaluate the potential role of these agents in the treatment of R/R disease.
  • Evaluate the biologic rationale for the investigation of CD19-directed CAR (chimeric antigen receptor) T-cell therapy for CLL, and identify patients who may be appropriate for ongoing studies.
  • Recall available and emerging data with novel agents and combination strategies currently under investigation for CLL, and refer appropriate eligible patients for clinical trial participation.

CME Credit Form
A CME credit form will be given to each participant at the conclusion of the activity.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 2 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations. Faculty disclosures to be provided.

Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, BeiGene Ltd, Genentech, a member of the Roche Group, Lilly, Pharmacyclics LLC, an AbbVie Company and Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC.

Hyatt Regency New Orleans
601 Loyola Avenue
New Orleans, LA 70113
Phone: (504) 561-1234

Meeting Room
Celestin Ballroom ABCD (Level 3)

Hyatt Regency New Orleans is conveniently located 6 minutes (1.1 miles) from the Ernest N Morial Convention Center, where the 64th ASH Annual Meeting is taking place. ASH will be providing complimentary shuttle service between the convention center and participating conference hotels. Shuttle schedule information will be made available on the ASH conference website and also posted in the lobby of participating hotels.

This activity is intended for hematologists, medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of chronic lymphocytic leukemia.

There is no fee to participate in this hybrid event. For the in-person symposium in New Orleans preregistration is required as seating is limited.
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IN-PERSON registration for clinicians in practice/healthcare professionals

I am a practicing physician, fellow, nurse or other healthcare provider involved in the treatment of cancer.

In-Person Registration for clinicians in practice »
IN-PERSON registration for other/industry professionals*

Please note, a limited number of seats are currently available for nonclinicians on a first come, first served basis.

In-Person Registration for other/industry professionals »

* Individuals employed by for-profit organizations, including financial institutions, biotech or pharmaceutical companies
LIVE WEBCAST registration for all professionals

Please note we will stream this event over Zoom. After registering you will receive a separate confirmation from Zoom with the viewing instructions.


Registration for groups
If you are registering a group (more than 1 person) for this event, please contact us at or (800) 233-6153.
To ensure seating and meal service, please check in at our onsite registration desk at least 30 minutes before the start of the meeting. We cannot guarantee seating after the start of the program.

Photography and/or video recording may be taken during the educational program by Research To Practice and used in future educational offerings.

Research To Practice fully complies with the legal requirements of the ADA. If you are in need of assistance (ie, physical, dietary, et cetera), please contact us prior to the event at (800) 233-6153.